Core protein: A pleiotropic keystone in the HBV lifecycle

HBV Core Protein Enhances Cytokine Production

Hepatitis B virus (HBV) infection, a cause of hepatocellular carcinoma (HCC), remains a serious global health concern. HCC development and human hepatocarcinogenesis are associated with hepatic inflammation caused by host interferons and cytokines. This article focused on the association between the HBV core protein, which is one of the HBV-encoding proteins, and cytokine production. The HBV co...

EZH2: a pleiotropic protein.

EZH2 (polycomb repressive complex 2 [PRC2] subunit) is the central core component of the PRC2, a multiprotein complex that methylates lysine 27 of histone 3 (H3K27) and acts as a transcriptional repressor by silencing expression of various target genes (see figure, path 1). The PRC2 complex is involved in a number of important physiological processes, including X-chromosome inactivation, stem c...

The Nuclear Localization Signal of HBV Core Protein : Characterization by Expression as EGFP-Core Fusion Proteins

Mutations in pre-core and basal-core promoter regions of hepatitis B virus in chronic HBV patients from Golestan, Iran

Objective(s): It has been reported that the mutation of the pre-core (PC) and basal-core promoter (BCP) may play an important role in the development of HBV-related hepatocellular carcinoma (HCC). In this study the PC and BCP mutations were investigated in chronic HBV patients. Materials and Methods:In this study, 120 chronic HBV patients from Golestan, Northeast of Iran who were not vaccinated...

A Manufacturing Core Concepts Ontology for Product Lifecycle Interoperability

This paper proposes a manufacturing core concepts ontology (MCCO) aimed at providing support for product life cycle interoperability. The potential focus of the work is interoperability across the production and design domains of product lifecycle. A core set of manufacturing concepts and their key relationships are identified in MCCO. Semantics are captured formally through heavyweight logic u...